Webinclusion morphology and cellular specificity. Thus, tauopathies may be subdivided into disorders with inclu-sions made predominantly of 3R or 4R tau or an admixture of both (Lee et al. 2001). These differences may be demonstrated by IHC using 3R- and 4R-specific antibodies and by different banding patterns seen on Four-repeat (4R) tauopathy with neuronal and glial tau inclusions. This intronic mutation stregthens the splice acceptor site, resulting in more frequent inclusion of exon 10 into mRNA transcripts. Malkani et al., 2006; Olszewska et al., 2024: N279K: FTD : Pathogenic: Substitution: Splicing Alteration Isoform Shift; Missense: Coding : Exon 10
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