Granulophysin

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August undefined, 2024

WebCD63 was first described in granules of resting platelets and on the surface membrane on activated platelets. CD63 was later identified as granulophysin, a platelet dense granule glycoprotein. The molecular … WebNov 6, 2024 · Level of granulophysin on the platelet surface. A, 5‐ HT /catecholamine‐treated or ‐untreated platelets were evaluated by measuring the level of granulophysin, a surrogate marker for dense‐granule …

CD63 Antibodies - Beckman Coulter Life Sciences

WebCD63 antigen, Granulophysin, Lysosomal-associated membrane protein 3, Lysosome integral membrane protein 1, Melanoma-associated antigen ME491, Ocular melanoma-associated antigen, OMA81H, Tetraspanin-30, CD63_HUMAN WebUniProt Accession Number of Target Protein: P08962 Alternative Name(s) of Target: Granulophysin; LAMP-3; ME491; MLA1; OMA81H; TSPAN30; LAMP3 Immunogen: Human monocytes. Specificity: This antibody binds to CD63 on monocytes and activated neutrophils. Application Notes: This antibody binds to CD63, a membrane-spanning … smardy blue r100 wasserbar

Granulophysin is located in the membrane of azurophilic ... - PubMed

WebJun 1, 1994 · Granulophysin expression on the surface membrane of the neutrophil is increased following stimulation of the cells, demonstrated by flow cytometry and fine structural immunocytochemistry. A similar pattern is shown for an anti-CD63 antibody. Incubation of activated neutrophils with D545, a monoclonal antibody to granulophysin, … WebAnti-CD63 (LAMP3), clone ME491, Cat. No. MABF2159, is a mouse monoclonal antibody that detects CD63 antigen and has been tested for use in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), and Western Blotting. Immunohistochemistry (Paraffin) Analysis: A 1:250 dilution from a representative lot … WebGranulophysin (CD63) is a protein in the tetraspanin group and is found in, among others, the dense granules and the α-granules of platelets [139,140], as well as the azurophilic granules of ... hiley mazda or arlington

Human CD63 ELISA Kit - Invitrogen - Thermo Fisher Scientific

WebNaked mole-rats are long-lived animals that show unusual resistance to hypoxia, cancer and ageing. Protein deimination is an irreversible post-translational modification caused by the peptidylarginine deiminase (PAD) family of enzymes, which convert arginine into citrulline in target proteins. Protein deimination can cause structural and functional protein changes, … WebAbout This Kit. Human CD63 quantitates human CD63 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human CD63. CD63 (LAMP-3, lysosome-associated membrane protein-3), a glycoprotein of tetraspanin family, is present in late endosomes, lysosomes and secretory vesicles of various cell types. smardy blue wasserbarWebSep 1, 1992 · Granulophysin levels were only low in forms of delta-SPD associated with albinism. Granulophysin levels in platelet homogenates of 30 patients with the Hermansky-Pudlak syndrome form of delta-SPD were 1/4 to 1/5 of levels in controls or obligate heterozygotes. Two patients with the Chediak-Higashi form of delta-SPD syndrome also … hiley philippines

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Granulophysin

WebJul 1, 1992 · We recently reported the characterization of a platelet granule membrane protein of molecular weight (mol wt) 40,000 called granulophysin (Gerrard et al: Blood … WebJun 15, 2000 · It can only be identified by GPIb-specific expression on its plasma membrane (pm). Granulophysin labels the membrane of vacuolar structures, which can be …

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WebGRANULOPHYSIN HGNC Approved Gene Symbol: CD63 Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:55,723,535-55,730,041 (from NCBI) TEXT Cloning … WebThe H5C6 monoclonal antibody specifically binds to CD63. CD63 is a 53 kDa, type III lysosomal glycoprotein, expressed on activated platelets, monocytes and macrophages. This molecule is also referred to in the literature as LIMP, gp55, melanoma-associated antigen ME491, Pltgp40, LAMP-3 and is a member of the tetraspan transmembrane 4 …

WebGranulophysin, a protein described in platelet dense granule membranes, has been shown to be similar or identical to CD63, a lysosomal membrane protein. We have previously shown granulophysin to ...

WebJun 1, 1994 · Abstract. Granulophysin, a protein described in platelet dense granule membranes, has been shown to be similar or identical to CD63, a lysosomal … Webprotein called granulophysin ( 15, 16), which is decreased in the Hermansky-Pudlak syndrome (15, 17). Ourresults thus providethefirstidentification …

WebLesley R. de Armas, Eckhard R. Podack, in Natural Killer Cells, 2010 Granulysin. Granulysin is a member of the saposin-like protein (SAPLIP) family that is also a component of …

WebJun 15, 2000 · Arrowheads indicate granulophysin (10-nm gold particles), and arrows indicate α-granule marker von Willebrand factor (5-nm gold particles). Both proteins can be found within the same MVB, but they are segregated from each other in distinct microvesicles. Granulophysin is also preferentially associated with the limiting … hiley mazda of hurst txWebThe immunological crossreactivity between the two granule‐specific membrane glycoproteins, synaptophysin and granulophysin, was studied using a series of … smardy blue wasserbar miranWebHuman CD63 antigen, also referred to as Granulophysin, Lysomal-associated membrane protein 3 (LAMP-3), Tetraspanin-30, and Ocular melanoma-associated antigen, is a membrane bound protein encoded by the gene CD63. CD63 belongs to a group of proteins known as the tetraspanin family, which are characterized by the presence of four … hiley of ft worthWebGranulophysin Lysosomal-associated membrane protein 3 LAMP-3 Melanoma-associated antigen ME491 OMA81H Ocular melanoma-associated antigen Tetraspanin-30 Tspan-30 CD antigen CD63. From Uniport. CD63 Gene family protein . CD molecules . Approved symbol Common name; BTN3A1: BTN3A1 protein, recombinant: LAMP1: hiley pre owned carsWebNormal human peripheral blood cells were stained with CD193 (CCR3) Monoclonal Antibody, PE (Product # 12-1939-42) and IgE Monoclonal Antibody, FITC (Product # 11-6986-42) only (blue histogram), or stained with CD63 Monoclonal Antibody, NovaFluor Red 700 (Product # H074T03R03) (purple histogram). hiley mazda white settlementWebCD63 molecule. Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and ... smardy blue wasserbar nouraWebDec 26, 2024 · Design and methods: The analysis of platelet surface proteins (Glycoprotein Ib-IX (CD42b, CD42a), Glycoprotein IIb-IIIa (CD41, CD61), p-selectin (CD62P), … hiley preowned